SLU-PP-332 Exercise Mimetic
A pan-estrogen-related receptor (ERR) agonist studied for skeletal muscle endurance and exercise-mimetic effects.
Book Free ConsultationCall 310.299.4444What SLU-PP-332 actually is
SLU-PP-332 is a pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by Burris and colleagues at Saint Louis University. ERRs are orphan nuclear receptors that regulate skeletal muscle mitochondrial biogenesis, fatty acid oxidation, and oxidative metabolism.1
In mouse models, SLU-PP-332 produced increased running endurance, mitochondrial biogenesis, and shifts toward oxidative metabolism — striking exercise-mimetic effects without exercise. Human clinical data is not yet available; we prescribe it as an experimental research compound under informed-consent framing.2
At Luxbae, SLU-PP-332 is prescribed and supervised by Dr. Ernst von Schwarz, MD, PhD after a complimentary medical consultation.
Mechanism — Estrogen-related receptor activation
Agonist at ERRα/β/γ, driving transcriptional programs for mitochondrial biogenesis and oxidative metabolism in skeletal muscle.1
What the research shows
Endurance mimetic. Increased running endurance in aged mouse models.2
Mitochondrial biogenesis. Drives mitochondrial biogenesis transcriptional programs.
Fatty acid oxidation. Shifts skeletal muscle toward oxidative metabolism.
Side effects: Very limited human data. Theoretical adverse effects related to chronic ERR activation — unknown long-term.
FDA note: Not FDA-approved. Experimental research compound. Prescribed at Luxbae only under explicit, detailed informed consent.
SLU-PP-332 FAQ
Is this safe in humans?
Long-term human data is essentially absent. Use is experimental.
Does it replace exercise?
Animal data is striking; human evidence is sparse. Should not substitute for activity.
References
- Billon C, Sitaula S, Banerjee S, et al. Synthetic ERR ligands rescue mitochondrial dysfunction. Sci Transl Med. 2023.
- Burris TP, Solt LA, Wang Y, et al. Nuclear receptors and their selective pharmacologic modulators. Pharmacol Rev. 2013.
- Eichner LJ, Giguère V. Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks. Mitochondrion. 2011.