What NAD+ actually is

Nicotinamide adenine dinucleotide (NAD+) is a central cellular coenzyme involved in redox reactions, sirtuin-mediated deacetylation, and PARP-mediated DNA repair. NAD+ levels decline with age, and the cellular consequences of this decline are an active area of longevity research.¹

At Luxbae we offer NAD+ via IV infusion (higher peak levels, longer protocols) and subcutaneous injection (more convenient, lower peak). Both routes increase systemic NAD+ availability and support sirtuin and PARP function.²

At Luxbae, NAD+ is prescribed and supervised by Dr. Ernst von Schwarz, MD, PhD after a complimentary medical consultation.

Mechanism — Coenzyme of sirtuins and PARPs

NAD+ serves as substrate for sirtuin deacetylation, PARP DNA repair, and mitochondrial electron transport — central to cellular bioenergetics.¹

What the research shows

Sirtuin support. Substrate for sirtuin-mediated longevity signaling.¹

PARP function. DNA repair function depends on NAD+ availability.

Mitochondrial energy. Electron transport and ATP production require NAD+.

Side effects: During IV infusion: chest pressure, nausea, flushing — rate-dependent. Subcutaneous: injection-site reactions, transient flushing.

FDA note: NAD+ is not FDA-approved as a parenteral therapeutic; compounded under physician supervision.

NAD+ FAQ

IV or subcutaneous?
IV delivers higher peak levels but is more involved; subcutaneous is convenient. Goal drives choice.

How fast do I notice?
Energy effects often within sessions of IV or weeks of consistent subcutaneous.

References

1. Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213.
2. Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27(3):513-528.
3. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-471.