What 5-Amino-1MQ actually is

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is elevated in adipocytes of obese individuals; its inhibition increases cellular NAD+ availability and shifts adipocyte metabolism toward energy expenditure.¹

Although technically a small molecule rather than a peptide, 5-Amino-1MQ is commonly co-prescribed in peptide practice as part of metabolic and longevity protocols. Animal data shows reduced adiposity and improved metabolic markers; human clinical experience is emerging.²

At Luxbae, 5-Amino-1MQ is prescribed and supervised by Dr. Ernst von Schwarz, MD, PhD after a complimentary medical consultation.

Mechanism — NNMT inhibition

Inhibits NNMT enzyme in adipocytes, reducing methyl-pool drain on NAD+ precursors and shifting energy metabolism toward expenditure.¹

What the research shows

NAD+ preservation. Reduced NNMT-driven methyl drain preserves cellular NAD+ pool.¹

Adipocyte metabolism. Animal data shows reduced adiposity and improved metabolic profile.²

Energy expenditure. Shift toward energy expenditure rather than storage in adipocytes.

Side effects: Limited human data. Mild GI symptoms, occasional headache reported anecdotally.

FDA note: Not FDA-approved. Investigational; prescribed under physician supervision.

5-Amino-1MQ FAQ

Is this a peptide?
Technically a small molecule, but commonly co-prescribed in peptide protocols.

How does it interact with NAD+?
Reduces NNMT-mediated drain on NAD+ precursors; complements direct NAD+ supplementation.

References

1. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262.
2. Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of NNMT. Biochem Pharmacol. 2018;147:141-152.
3. Pissios P. Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. Trends Endocrinol Metab. 2017;28(5):340-353.